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Humans
contract malaria from the bite of malaria infected female mosquitos.
When bitten, the mosquito injects saliva containing the infectious
form of the malaria parasite, known as a sporozoite, into a person's
bloodstream. These threadlike sporozoites circulate in the blood
for a short time.
Eventually, some of the sporozoites make their way to the liver,
where they enter the liver cells. Once inside a liver cell, each
sporozoite develops into a schizont, a structure that will eventually
contain thousands of tiny rounded merozoites.
When the schizont matures,
the liver cell ruptures and these merozoites are released into the
bloodstream. This process may take as little as 8 days or as long
as several months.
Merozoites released from the liver rapidly invade red blood cells
where they multiply. In the process of multiplying the red blood
cells rupture releasing more merozoites back into the blood.
This process continues until most of the red blood cells are either
infected or destroyed.
A small number of the merozoites may develop into male and female
gametocytes. If the person
is bitten by an uninfected female mosquito, these are taken up and
the mosquito now becomes capable of infecting other humans.
With the release of merozoites
into the blood, patients often develop symptoms. For
most people, symptoms begin 10 days to 4 weeks after initial infection.
Such symptoms include fever, chills, joint pain, headache, vomiting
and tiredness. Because of the destruction of red blood cells, patients
also often develop anemia, and if not treated, malaria infections
can progress to severe disease and even death.
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